Immunogenetics of human haptoglobins

Immunogenetics of Human Haptoglobins

A B S T R A C T Using a radioimmunoassay method in conjunction with double diffusion studies, we characterized the antigenic determinants of the three Hp Bellevue phenotypes. An antigenic model based on these data indicates that each phenotype comprises a heterogeneous group of proteins with properties depending on their content of normal (hp,8) and of mutant (hp,8Bellevue) chains of haptoglobi...

Immunogenetics of human haptoglobins. I. The antigenic structure of normal Hp phenotypes.

The various antigenic determinants of serum haptoglobins (Hp) may be studied semiquantitatively in a radioimmunoassay system. Using three antisera of overlapping specificities, we constructed an antigenic model of the various Hp phenotypes comprising four distinct determinants. This adds a new determinant, situated near the hemoglobin binding site, to the three determinants reported in the lite...

Immunogenetics Human immunogenetics Editorial overview

Charles Larsen trained as a protein chemist and has studied the biophysics of viral membrane fusion. His current interest is the cellular immunology and genetics of the human nonresponse to hepatitis B vaccine. This interest has broadened to include the relationship between MHC genetic structure and autoimmune phenomena. Abbreviations CEH conserved extended haplotype KIR killer immunoglobulin-l...

The determination of haptoglobins in normal human serum.

Human Immunogenetics. Basic Principles and Clinical Relevance

Human Immunogenetics is one of 46 volumes in a continuing series of books related to specific topics in immunology. This lengthy volume is divided into five major areas of immunogenetics: experimental approaches to immunogenetics, genetics of immunology, the major histocompatibility complex, tumor and viral antigens, and blood and serum components. All chapters are introduced with a basic revie...